WuXi Biologics (“WuXi Bio”) (2269.HK), a leading global Contract Research, Development, and Manufacturing Organization (CRDMO), today announced the launch of WuXia™ RidGS, a high-yield glutamine synthetase (GS)-knockout Chinese hamster ovary (CHO) expression system platform. The platform, specialized in non-antibiotic cell line development, employs zinc finger nucleases (ZFN) technology for targeted knockout of the endogenous GS gene in CHO cells.
Based on the WuXia™ platform, WuXia™ RidGS not only retains the robust cell growth, metabolism, and expression profile characteristic of WuXia™, but also boasts an average clonal expression level exceeding 6 g/L for monoclonal antibodies(mAbs). WuXia™ RidGS ensures cell line stability for mAbs, as well as for various other therapeutic modalities, including bispecific antibodies, Fc-fusion proteins, and recombinant proteins. The quality of protein products expressed by the platform showcases favorable glycosylation patterns while maintaining an exceptional purity profile. In addition, without the need for antibiotics, WuXia™ RidGS host and production cells consistently maintain stable productivity and uniform product quality throughout extensive, long-term cell line stability studies.
Dr. Chris Chen, CEO of WuXi Biologics, commented, “With the launch of WuXia™ RidGS, we are pleased to offer a more efficient alternative for the development of advanced therapeutic proteins. WuXi Biologics continues its commitment to developing tailored technology platforms that cater to the evolving needs of our global clients, accelerating the speed to market for life-saving therapies and advancing the accessibility of high-quality biologics for patients worldwide.”
