This White Paper explores key issues of Artificial Intelligence (AI) that present both huge opportunities and new challenges for information and communication technologies (ICT). AI is becoming central to ETSI’s mission of “being at the heart of digital”. Standardization is understood to be a necessary tool in the efficient exploitation of these opportunities, both in Europe and globally. This White Paper details current initiatives and recommends future directions for the ETSI community and the ICT industry in general. ETSI technical bodies are already addressing numerous aspects of using AI in ICT systems. These include 5G systems, network planning and optimization, service provisioning and assurance, operator experience, security, IoT, data management and testing. eHealth and Human Factors technical bodies are considering the use cases for AI and their potential impact on people.